PerkinElmer

吉林快三分析神器:Microplate Readers

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Performance, Versatility, and Reliability for Today’s Laboratory Needs

As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate. This is where it all starts for your basic research, assay development and therapeutic research. A powerful and reliable plate reader is what you need for your scientific breakthroughs or delivering new drugs and therapeutic treatments to market. It is a crucial component and workhorse for every lab to identify the ideal drug compound to advance it from discovery to development to manufacturing.

Industries that can benefit:

  • For academia – the need for low-throughput performance and all major detection technologies to run everyday biochemical and cell-based assays
  • For pharmaceutical, biotechnology and clinical research organization – the need for high sensitivity, speed, and throughput to perform complex assays with the desire to customize for automation
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Configurable Multimode Plate Readers to Future Proof Your Lab

Multimode plate readers have become very popular. Market demand has driven instrument manufacturers to progress from producing single-mode plate readers to those with multiple modes of detection. They offer flexibility and savings in cost and precious lab space, together with the convenience of employing only one instrument versus having to purchase multiple dedicated instruments.

Our multimode microplate readers offer all major detections such as Absorbance, Alpha, Luminescence, Fluorescence Intensity, Fluorescence Polarization, and Time-Resolved Fluorescence, all in one instrument. And they are configurable so you can add detection technologies when you need to future proof your lab. They are ideal for applications such as cell viability/proliferation/toxicity, drug screening, pathway analysis, receptor panning, biomarkers, protein:protein interaction, gene expression, food monitoring, and epigenetics.

PerkinElmer’s portfolio of plate readers is equipped with the latest detection technologies to meet the diverse assay requirements of labs today. With over 30 years of experience in instrument development, you can expect performance and reliability from any of our microplate readers.

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Types of Detection Technologies

Absorbance

Well-Established Assay

Absorbance is the measurement between the amount of light being absorbed by a sample and the light that passes through the sample (non-absorbed). A specific wavelength of light is usually selected from an optical filter. It is one of the most well-established microplate assay formats and perfect for assays such as ELISA, protein and nucleic acid quantification, and enzyme activity.

Alpha

Assay for Virtually Any Application

Alpha is a high-performance laser-based technology, validated for use with our proprietary AlphaScreen? and AlphaLISA? assay kits. It has the power to assay the most complex samples – all in one well, with no wash steps. Alpha Technology enables fast, simple, highly sensitive detection of biomolecules in cell lysates, cell supernatants, serum, and a variety of other sample types. Laser-based Alpha detection allows you to have quick readouts, while maintaining a high signal-to-background ratio.

Luminescence

Ideal for Reporter Gene, Cytotoxicity, and Proliferation Assays

Luminescence is the measurement of light emitted as a result of a chemical or biochemical reaction with no excitation energy. A luminescence assay is extremely useful as a detection platform because of its wide dynamic range, greater sensitivity than fluorescence technologies and lower interference than other detection options. Luminescence assay formats include glow and BRET, and flash or dual glow – perfect for applications such as reporter gene, cytotoxicity, and proliferation assays.

Fluorescence Intensity

Popular Light Emission Detection

Fluorescence Intensity is the measurement of light emitted from a molecule (fluorophore) at one wavelength and light excited at a shorter wavelength. It is one of the most popular detection modes, and there are innumerable fluorophores available for applications such as DNA or protein quantitation, reporter-gene expression, and protein binding.

Fluorescence Polarization

Ideal Detection for High Throughput

Similar to Fluorescence Intensity, Fluorescence Polarization is based on the emission of light by an excited fluorophore. For this detection, samples are excited by polarized light using specific filters. It is generally applied to measure binding events between small and large molecules. Fluorescence Polarization is a homogeneous assay technology that’s ideal for high-throughput screening. Fluorescein is the commonly used fluorescent label and is suitable for typical applications such as receptor-ligand binding, protein interaction, or hapten immunoassays.

Time-Resolved Fluorescence

Enhanced Sensitivity and Dynamic Range for Immunoassays

Time-Resolved Fluorescence (TRF) uses fluorescent molecules, called lanthanides, that can emit light over long periods of time after excitation. Time-Resolved Fluorescence can help improve the sensitivity and dynamic range of your immunoassays, even when sample is at a premium or in low concentration. TRF detection, together with lanthanide-based DELFIA, LANCE, or HTRF chemistries, offers enhanced signal-to-background ratio, high sensitivity, wide dynamic range, superior stability, and excellent flexibility.

VICTOR Nivo Multimode Microplate Reader

VICTOR? Nivo? packs all the latest major detection technologies in the industry’s smallest benchtop footprint. The perfect microplate reader for everyday biochemical and cell-based assays. It measures at any wavelength, with top and bottom reading for most standard technologies. With its ease of use software and remote access from almost any device, it is ideal for multiuser environments.

  • Smallest and most affordable multimode plate reader in the industry
  • Certified for use with HTRF? technology
  • Best for research labs with multi-users and low-throughput assays

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EnSight Multimode Microplate Reader

EnSight? offers both fast well-imaging and multimode detection capabilities for target-based and phenotypic screening, all in a single benchtop instrument. It allows you to gain insights you couldn’t achieve with detection measurements alone. When combined with our Kaleido? workflow software, it increases productivity, makes it ideal for multiuser environments, and elevates the confidence in your scientific results.

  • Fast well-imaging, Alpha and conventional detection technologies, all in a single benchtop system
  • For research and assay development labs performing cell-based assays at medium-throughput

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EnVision Multimode Microplate Reader

EnVision? is our fastest benchtop multimode plate reader and it provides ultra-high throughput and maximum sensitivity across all detection technologies. With its exceptional speed and minimal downtime, it is ideal for complex assays to drive your scientific breakthroughs. In addition, our Enhanced Security software for regulated environments (GxP) will simplify your road to compliance so you can focus on the science.

  • Fastest benchtop reader in our portfolio
  • Certified for use with HTRF? technology
  • For screening or assay development labs needing high-throughput capability

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Configurable Key Features for Our Multimode Plate Readers

  VICTOR Nivo EnSight EnVision
UV-Vis Absorbance Filter or spectrometer Filter and quad monochromators Filter and/or quad monochromators
Fluorescence Intensity Filter Quad monochromator Filter and/or quad monochromators
Luminescence ?1   ?1
Ultrasensitive Luminescence   ? ?
TRF and TR-FRET Lamp based2 Lamp based Lamp or laser based2
Fluorescence Polarization ?   ?
Alpha (Laser-Based) Alpha Standard Alpha HTS Alpha Standard or Alpha HTS
AlphaPlex (Laser-Based)     Alpha Standard
Fast Image-based Cytometry   ?  
Dual PMT Detector     ?
1 - Capable of BRET/BRET2 assays.
2 - HTRF? Certified.

Drug Discovery Reagents

Drug discovery is a time-consuming and costly undertaking. From understanding pathways to target identification and then to hit and eventually compound, the transition needs to happen quickly and efficiently. Our drug discovery reagents help you do just that. Whether you are studying basic science to uncover pathways and learn more about disease states or screening for potential leads, we offer a wide range of validated reagents and kits in Alpha chemiluminescent, LANCE? Ultra TR-FRET, DELFIA? TRF, and other assay technologies to suit your assay needs. Together with our multimode microplate readers, they can provide relevant and reliable results to accelerate your drug discovery.

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